Radiosensitization of Prostate Cancer Cells by 2-Deoxyglucose
نویسندگان
چکیده
منابع مشابه
Chk1 knockdown confers radiosensitization in prostate cancer stem cells.
Radioresistance is responsible for treatment failure after radiotherapy in localized prostate cancer, while prostate cancer stem cells promote radioresistance by preferential activation of the DNA damage response. Chk1 inhibition has been shown to sensitize many tumor cells to radiation. However, whether Chk1 inhibition can potentiate the cytotoxi...
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Targeting cancer cell metabolism is a new promising strategy to fight cancer. Metformin, a widely used antidiabetic agent, exerts antitumoral and antiproliferative action. In this study, the addition of metformin to 2-deoxyglucose (2DG) inhibited mitochondrial respiration and glycolysis in prostate cancer cells leading to a severe depletion in ATP. The combination of the two drugs was much more...
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ژورنال
عنوان ژورنال: Madridge Journal of Oncogenesis
سال: 2018
ISSN: 2641-5267
DOI: 10.18689/mjo-1000105